【预订】Next Generation Sequencing 9781493985074
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/ 2018-06-22
Product Details 基本信息 ISBN-13 书号 9781493985074 Author 作者 Steven R. Head The Scripps Research Institute La Jolla CA Format 版本 平装-胶订 Pages Number 页数 266页 Publisher 出版社 Humana Press Publication Date 出版日期 2018-06-22 Language 语种 英语 Book Contents 内容简介 This volume covers a wide range of various fields of research, with the common thread being Next Generation Sequencing (NGS) related methods and applications, as well as analysis and interpretation of the data obtained. Chapters guide readers through the highly dynamic processes of translational and tran*ional profiling of a cell, method to detect copy number alterations (CNAs), targeted sequencing applications,? method called “Hi-Plex” to characterize known polymorphic loci, single-cell of DNA or RNA, identify and characterize rare circulating CD4 T cells, and computational pipeline for RNAseq analysis. Written in the highl
¥1129
【预订】Microbial Transposon Mutagenesis 9781493995691
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/ 2019-08-04
Product Details 基本信息 ISBN-13 书号 9781493995691 Author 作者 Steven C. Ricke Format 版本 精装 Pages Number 页数 200页 Publisher 出版社 Humana Press Publication Date 出版日期 2019-08-04 Language 语种 英语 Book Contents 内容简介 This book addresses cutting-edge techniques for researching transposon mutagenesis, an approach for identifying individual gene contributions to the phenotypic characteristics of a particular microorganism. The volume begins with methods for specific microorganisms and include protocols for individual microorganisms ranging from pathogens such as Salmonella to Bifidobacterium, a microorganism considered beneficial to humans and animals. The final section addresses more general protocols including plasmid transfer and bioinformatic tools as well as novel applications of transposon methodologies such as transposon-aided capture of antibiotic resistant plasmids. Written for the high
¥1752
【预订】Care of the Aged 9781617374449
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/ 2010-11-19
Product Details 基本信息 ISBN-13 书号 9781617374449 Author 作者 James M. Humber Format 版本 平装-胶订 Pages Number 页数 200页 Publisher 出版社 Humana Press Publication Date 出版日期 2010-11-19 Language 语种 英语
¥1143
【预订】Vaccinia Virus 9781493995929
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/ 2019-06-29
Product Details 基本信息 ISBN-13 书号 9781493995929 Author 作者 Jason Mercer Format 版本 精装 Pages Number 页数 352页 Publisher 出版社 Humana Press Publication Date 出版日期 2019-06-29 Language 语种 英语 Book Contents 内容简介 This detailed book provides practical information for the laboratory that can be applied to the study of vaccinia and other poxviruses while emphasizing long-standing field standards and focusing on emerging new technologies applied in the field of poxvirology. The methods and protocols have been designed with the bench scientist in mind, being presented in a fashion that makes them useful for both starting and veteran poxvirus researchers. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on
¥2006
【预订】Matrix Metalloproteinase Inhibitors in Cancer Therapy 97
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/ 2000-09-17
Product Details 基本信息 ISBN-13 书号 9780896036680 Author 作者 Neil J. Clendeninn Format 版本 精装 Pages Number 页数 262页 Publisher 出版社 Humana Press Publication Date 出版日期 2000-09-17 Language 语种 英语 Book Contents 内容简介 Cutting-edge investigators review the current status of the entire field, from the biology of MMPs through the current clinical studies. The authors include many leading scientists from pharmaceutical companies who present all the latest concepts and results on the preferred design strategies for MMP inhibitors, their molecular mechanisms, and their substrates. In addition, they fully describe their personal research on specific MMP inhibitors, detailing vanguard design strategies, their in vitro activity, the outcome of animal model studies and, where available, their toxicology, safety, efficacy in human clinical trials. Comprehensive and state-of-the-art, Matrix Metallopro
¥1450
【预订】Target Discovery and Validation Reviews and Protocols 97
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/ 2007-02-05
Product Details 基本信息 ISBN-13 书号 9781588298904 Author 作者 Mouldy Sioud Format 版本 精装 Pages Number 页数 345页 Publisher 出版社 Humana Press Publication Date 出版日期 2007-02-05 Language 语种 英语 Book Contents 内容简介 Target Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target disco
¥1022
【预订】Metabolic Flux Analysis in Eukaryotic Cells 978107160158
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/ 2020-01-01
Product Details 基本信息 ISBN-13 书号 9781071601587 Author 作者 Deepak Nagrath Format 版本 精装 Pages Number 页数 462页 Publisher 出版社 Humana Press Publication Date 出版日期 2020-01-01 Language 语种 英语 Book Contents 内容简介 This volume explores the latest metabolic flux analysis (MFA) techniques that cover the analysis of cellular, organ level, and whole-body metabolism. The chapters in this book discuss topics such as deutrium tracing; isotopologue fractions using GC-TOF; non-targeted mass isotopolome analysis; large-scale profiling of cellular metabolic activities using deep 13C labeling medium; metastases in mice; SWATH; Exo-MFA; metabolic flux from time-course metabolomics; and thermodynamic approaches in flux analysis. Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents
¥1470
【预订】Cystic Fibrosis 9783030423810
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/ 2020-06-13
Product Details 基本信息 ISBN-13 书号 9783030423810 Format 版本 精装 Pages Number 页数 526页 Publisher 出版社 Humana Press Publication Date 出版日期 2020-06-13 Language 语种 英语 Book Contents 内容简介 This book provides a comprehensive overview of the multisystem disease, cystic fibrosis, for both pediatric and adult patients. Written by experts in the field, the text outlines the progressive nature of CF as well as the impact of this autosomal recessive disease on the respiratory, gastrointestinal, endocrine, rheumatologic, and renal systems, as well as the patient’s mental health. The book begins with a chapter describing the history of cystic fibrosis and how the face of this life-shortening disease has changed over the past several decades. The following chapters elucidate the pathophysiology of how cystic fibrosis impacts each organ system. Current management and therapeutics are detailed with step-by-ste
¥1684
【预订】Neurohistology and Imaging Techniques 9781071604267
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/ 2020-05-23
Product Details 基本信息 ISBN-13 书号 9781071604267 Author 作者 Radek Pelc Format 版本 精装 Pages Number 页数 528页 Publisher 出版社 Humana Press Publication Date 出版日期 2020-05-23 Language 语种 其它(含多语) Book Contents 内容简介 This volume explores major light microscopic imaging modalities that can be used to view nervous tissue, and discusses the steps needed to use each of them, and ways to interpret the data. The chapters in this book cover topics such as atlasing of insect brain; neuroanatomical tracing through fluorochrome expression; fluorescent probes for amyloids; or optical clearing for ultramicroscopy of GFP-?expressing tissues. In theNeuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Authoritative and cutting-edge, Neurohistology and Imaging Techniques is a valuable resource for both
¥1494
【预订】Cell Culture Techniques 9781493992270
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/ 2019-05-02
Product Details 基本信息 ISBN-13 书号 9781493992270 Author 作者 Michael Aschner Format 版本 精装 Pages Number 页数 340页 Publisher 出版社 Humana Press Publication Date 出版日期 2019-05-02 Language 语种 英语 Book Contents 内容简介 This volume discusses the requirements, advantages, and limitations of studying cell culture. The chapters in this book cover topics such as in vitro blood-brain barrier functional assays in human iPSC-based models; neuron-glia interactions examines with in vitro co-culture; epigenetic changes in cultures neurons and astrocytes; rat brain slices; brain punching technique; and using microRNA for in vitro neurotoxicity testing and related disorders. In Neuromethodsseries style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Authoritative and cutting-edge, Cell Culture Techniques, Second Edition is a valuab
¥1791
【预订】Hemorrhagic Fever Viruses 9781493983582
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/ 2018-08-22
Product Details 基本信息 ISBN-13 书号 9781493983582 Author 作者 Maria S. Salvato Format 版本 平装-胶订 Pages Number 页数 425页 Publisher 出版社 Humana Press Publication Date 出版日期 2018-08-22 Language 语种 英语 Book Contents 内容简介 This volume presents protocols that analyze and explore hemorrhagic fever viruses (HFV). This book is divided into 5 parts: Part I begins with an overview on predicting viral pandemics and then covers methods for surveillance, diagnosis, and classification of HFV. This includes an antibody capture method using Lassa virus antigens. Part II discusses structural studies and reverse genetics of HFV. The chapters in this part describe envelope glycoprotein membrane fusion studies, arenavirus nucleocapsid protein, and the use of virus-like-particles to study viral egress. Part III explores in vivo models of HFV infections, and contains chapters on murine, guinea pig, and prima
¥1149
【预订】The Linc Complex: Methods and Protocols 9781493993673
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/ Humana
Product Details 基本信息 ISBN-13 书号 9781493993673 Format 版本 平装-胶订 Pages Number 页数 338页 Publisher 出版社 Humana Publication Date 出版日期 1800-01-01 Language 语种 英语
¥1143
【预订】Proteomic Profiling 9781493949540
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/ 2016-10-29
Product Details 基本信息 ISBN-13 书号 9781493949540 Author 作者 Posch Format 版本 平装-胶订 Pages Number 页数 501页 Publisher 出版社 Humana Press Publication Date 出版日期 2016-10-29 Shipping Weight 商品重量 1143g Language 语种 英语 Book Contents 内容简介 This volume presents the latest developments of the main pillars of protein analysis, such as sample preparation, separation and characterization. The book begins by describing basic but important sample preparation protocols. It then goes on to describe more sophisticated procedures on enriching specific protein classes and concludes with detailed de*ions of integrated work-flows for comprehensive protein analysis and characterization. The authors of the individual chapters are renowned protein biochemists who have all set value to provide a detailed representation of their lab work. Throughout the chapters, these authors share important tip
¥1612
【预订】Macrophages: Methods and Protocols 9781493993000
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/ Humana
Product Details 基本信息 ISBN-13 书号 9781493993000 Format 版本 平装-胶订 Pages Number 页数 278页 Publisher 出版社 Humana Publication Date 出版日期 1800-01-01 Language 语种 英语
¥1248
【预订】Genotoxicity and DNA Repair 9781493948291
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/ 2016-09-17
Product Details 基本信息 ISBN-13 书号 9781493948291 Author 作者 L. María Sierra Universidad de Oviedo Oviedo Spain Format 版本 平装-胶订 Pages Number 页数 483页 Publisher 出版社 Humana Press Publication Date 出版日期 2016-09-17 Shipping Weight 商品重量 935g Language 语种 英语 Book Contents 内容简介 Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the “OECD guidelines for the testing of chemicals”, this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical
¥1143
【预订】Ecotoxicological QSARs 9781071601495
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/ 2019-12-25
Product Details 基本信息 ISBN-13 书号 9781071601495 Author 作者 Kunal Roy Format 版本 精装 Pages Number 页数 972页 Publisher 出版社 Humana Press Publication Date 出版日期 2019-12-25 Language 语种 英语 Book Contents 内容简介 This volume focuses on computational modeling of the ecotoxicity of chemicals and presents applications of quantitative structure–activity relationship models (QSARs) in the predictive toxicology field in a regulatory context. The extensive book covers a variety of protocols for de*or computation, data curation, feature selection, learning algorithms, validation of models, applicability domain assessment, confidence estimation for predictions, and much more, as well as case studies and literature reviews on a number of hot topics. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of practical advice that is essential for researchers everywhere.A
¥2080